A synthesis of 11-nor-9-ketohexahydrocannabinol
نویسندگان
چکیده
منابع مشابه
Mini - Review 11 - Nor - 9 - carboxy - ∆ 9 - tetrahydrocannabinol – a ubiquitous yet underresearched cannabinoid . A re - view of the literature
Synthetic ∆ 9 -tetrahydrocannabinol (THC), pharmaceutical grade herbal cannabis as well as formulations of well-defined cannabis extracts are available as registered medicines in several countries. It is generally accepted that the main central and peripheral pharmacological effects of THC are mediated by CB1 and CB2 cannabinoid receptors. Cytochrome P450-mediated oxidations of THC afford the n...
متن کاملSynthesis of [13C4]-labeled ∆9-tetrahydrocannabinol and 11-nor-9-carboxy-∆9-tetrahydrocannabinol as internal standards for reducing ion suppressing/alteration effects in LC/MS-MS quantification.
(-)-∆9-Tetrahydrocannabinol is the principal psychoactive component of the cannabis plant and also the active ingredient in some prescribed drugs. To detect and control misuse and monitor administration in clinical settings, reference samples of the native drugs and their metabolites are needed. The accuracy of liquid chromatography/mass spectrometric quantification of drugs in biological sampl...
متن کاملEffects of oxidizing adulterants on detection of 11-nor-delta9-THC-9-carboxylic acid in urine.
Bleach, nitrite, chromate, and hydrogen peroxide-peroxidase are effective urine adulterants used by the illicit drug users to conceal marijuana-positive results. Methods for detecting nitrite and chromate are available. Effects of other oxidizing agents that could possibly be used as adulterants and are difficult to detect or measure are presented in this report. Urine samples containing 40 ng/...
متن کاملUrinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence.
The time course of 11-nor-9-carboxy-Delta9-tetrahydrocannnabinol (THCCOOH) elimination in urine was characterized in 60 cannabis users during 24 h monitored abstinence on a closed research unit for up to 30 days. Six thousand, one hundred fifty-eight individual urine specimens were screened by immunoassay with values > or = 50 ng/mL classified as positive. Urine specimens were confirmed for THC...
متن کاملUrinary excretion profiles of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol in humans after single smoked doses of marijuana.
Interpretation of marijuana-positive urine tests requires an understanding of the excretion pattern of marijuana metabolites in humans. However, limited urinary excretion data from controlled clinical studies of marijuana use are available. In this study, six subjects smoked a single marijuana cigarette (placebo, 1.75% delta 9-tetrahydrocannabinol [THC], or 3.55% THC) each week while residing o...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1982
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v82-047